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Why Nausea & Migraines Are Linked Through the Gut-Brain Axis
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Why Nausea & Migraines Are Linked Through the Gut-Brain Axis

12 min

Is nausea really just a migraine side effect? Discover how your gut and brain work together to trigger pain, inflammation, and discomfort.

00:00
-12:00

Why do so many migraine attacks come with nausea, bloating, stomach discomfort, or digestive shutdown?

In this episode of The Migraine Heroes Podcast, host Diane Ducarme explores the powerful connection between migraines and the gut-brain axis. Blending neuroscience with holistic healing perspectives, this episode reveals why nausea is not “just a symptom,” but often part of the migraine process itself.

You’ll discover: 💡 Why nausea is deeply connected to the migraine process — not simply a secondary side effect 💡 How the gut-brain axis can increase inflammation, stress signaling, and nervous system overload during attacks 💡 Simple ways to calm your digestive system at home that may help reduce migraine-related nausea naturally If you’ve ever felt like your stomach and brain are reacting together during migraines, this episode will help you better understand the deeper connection behind your symptoms.

🎧 New episodes every Monday and Wednesday 🔗 Discover our work on migraineheroes.com

References:

  • **Pathophysiology of Migraine (Goadsby et al., 2017): **This review explains migraine as a disorder of sensory processing involving trigeminovascular pathways, altered brain excitability, and brainstem dysfunction. Read more here.
  • Gut Microbiota and Migraine (related alternative): This review explains how microbiota-mediated gut–brain crosstalk may contribute to migraine pathophysiology. Read more here.
  • Gastric Stasis in Migraine (Aurora et al., 2006): This paper examines delayed gastric emptying in migraine patients during and between attacks. Read more here.
  • The CGRP Pathway in Migraine (Edvinsson, 2018): This paper reviews CGRP as a key migraine pathway and therapeutic target. Read more here.
  • Gut Feelings: Gut–Brain Communication (Mayer, 2011): This review explores bidirectional communication between the gut and brain, including effects on digestion, emotion, motivation, and higher cognitive functions. Read more here.

Disclaimer: This podcast is for informational purposes only and does not substitute for providing medical advice. Always consult your healthcare professional before making any health-related decisions. For women, men, and children who suffer from migraine disease, Migraine Heroes is your go-to resource for understanding, managing, and overcoming migraine attacks. We cover all types of migraines and related headaches, including primary and secondary migraines, chronic migraines, and cluster migraines. We dive deep into the complexities of migraine with aura and migraine without aura, as well as rarer forms like hemiplegic migraine, retinal migraine, and acephalgic migraine (silent migraine). Our discussions also extend to cervicogenic headaches, ice pick headaches, and pressure headaches, which often mimic migraine or contribute to overall migraine burden.

Transcript

[00:00]

Have you ever wondered why a migraine can make your stomach completely revolt,

[00:04]

leaving you nauseous, unable to eat or even vomiting before the head's pain fully hits?

[00:10]

Today, we're diving into the fascinating and powerful connection

[00:14]

between your gut and your brain on nausea and migraine.

[00:20]

Welcome to Migraine Heroes, a podcast for people living with chronic migraines with years of pain,

[00:26]

misunderstanding and lack of answers. I'm Diane Ducarme. I've helped more than a thousand people

[00:33]

reduce the burden of migraines and feel more in control. My mission in life? To help a million

[00:39]

people. Each episode brings you grounded insight into what your body might be asking for and what

[00:46]

can truly help. Just to keep you fully supported, this podcast is educational. For diagnosis or

[00:54]

medication, always work with your doctor. Now, take a breath and let's dive in.

[01:06]

In this episode, you will learn why nausea is not just a side symptom of migraines but a core part

[01:11]

of the migraine process itself, how the gut-brain axis can amplify inflammation, stress signals and

[01:18]

nervous system overload that trigger migraine attacks, and a simple way to calm your digestive

[01:23]

system at home that may reduce the intensity of migraine-related nausea starting today.

[01:29]

Stay with me till the end because at the end of this episode, you will understand why

[01:33]

calming your gut may sometimes calm your migraine faster than focusing only on your head pain.

[01:40]

If you live with migraines, you probably know this feeling all too well. The wave of nausea,

[01:45]

sort of the sudden food aversion, the stomach cramping, the inability to digest properly,

[01:51]

that you have food in your stomach or not, or even vomiting during an attack. And honestly,

[01:57]

it can feel quite frightening at times. You may feel trapped between your brain and your stomach,

[02:03]

unable to function, eat or even think clearly. And if this is you, please know this. Your body

[02:09]

is not overreacting. There is a very real biological connection happening. The relationship

[02:14]

between migraine and nausea is deeply connected to what scientists now call the gut-brain axis.

[02:20]

And I'm sure you've heard of this. This is the two-way communication system between your

[02:25]

gastrointestinal tract and your central nervous system. And so your gut and your brain are

[02:30]

constantly talking to each other through your nerves, through your hormones, your immune signals,

[02:36]

and even your gut bacteria. And one of the key players here is the vagus nerve, which is often

[02:41]

called the superhighway between the gut and the brain. And the vagus nerve helps regulate digestion,

[02:47]

inflammation, heart rate, and stress responses. And during a migraine attack,

[02:51]

this communication pathway can become really disrupted. I don't know if you've ever watched

[02:56]

small children. So they sort of share an ice cream together and one of them suddenly eats it

[03:01]

far too quickly and grabs their forehead and laughs, brain freeze, and only to encourage the

[03:06]

other children to try it too. And it's very cute to watch, but it's also surprisingly revealing.

[03:11]

In this brief moment, the child is going to experience something completely profound.

[03:16]

It's going to experience for the first time the connection between their brain and their stomach.

[03:20]

When the stomach is suddenly exposed to intense cold, the sensation can travel upward and be

[03:26]

felt almost instantly in the forehead. It comes like a snap, sharp, sudden, but fleeting. And

[03:32]

the body reacts quickly, warming and melting the ice cream, almost immediately restoring that

[03:38]

balance. So what is fascinating is that the connection has been established. The child

[03:42]

intuitively realizes that the gas in the brain are deeply linked, that what happens in the stomach

[03:47]

does not stay in the stomach. The body speaks in pathways, echoes, and responses. So in the West,

[03:53]

we now know that the stomach can communicate continuously with the brain region involved in

[03:57]

emotions, stress, awareness, and cognition, including the prefrontal cortex. And research

[04:03]

published in Nature Reviews Neurology by Goatsby explained that migraines are not simply vascular

[04:10]

headaches that once we believed, but complex neurological events involving multiple systems,

[04:15]

including the digestive system. And during a migraine attack, the brainstem becomes activated,

[04:21]

particularly areas associated with nausea and vomiting. And this is going to include the

[04:26]

dorsal vagal complex, which directly influences the stomach function. So what does it mean in

[04:31]

practice? So it means your stomach may literally slow down during a migraine attack. This condition

[04:38]

is known as gastric stasis, where food is going to remain in the stomach longer than normal.

[04:45]

And studies published in the journal Cephalalgia found that migraine patients frequently experience

[04:51]

delayed gastric emptying, both during and between attacks. But why would that happen? Why would

[04:58]

nausea happen in the first place? Why would that gastric stasis happen in the first place?

[05:03]

Most nausea tends to come from five major events. The first one is irritation. Something

[05:09]

physically upsets your stomach. Food poisoning, it can be alcohol, a virus, overeating, reflux.

[05:15]

The body reacts almost protectively, saying, something here doesn't feel right. The second

[05:21]

comes from the balance system. And motion sickness here is a perfect example. So when your eyes,

[05:27]

your inner ears, and your body disagree about movement on a boat, or in turbulence, or in a car,

[05:33]

the brain can trigger nausea almost like an emergent response. So I don't know if you've

[05:38]

ever noticed, do you have more nausea and migraine while on the road? That's what I'm

[05:42]

talking about. The third involves hormones and chemistry. So pregnancy, hormonal shifts,

[05:48]

blood sugar crashes, all of these can activate nausea pathways because the brain is constantly

[05:53]

monitoring the chemistry of the body. The fourth is linked to stress and emotion. Most of us have

[05:58]

experienced this, this sick feeling before an exam. Nausea before public speaking, a sort of a

[06:04]

loss of appetite during grief or a heartbreak. And Western science now understands that the gut and

[06:09]

brain are in constant communication through what is called the gut-brain axis. So anxiety, fear,

[06:14]

overwhelm, and chronic stress can absolutely create physical nausea. And the fifth is protection.

[06:20]

Nausea is actually a survival mechanism. The body evolves to help protect us from toxins,

[06:26]

spoiled foods, infections, and danger. In many ways, nausea is the body choosing caution before

[06:32]

catastrophe. Because during a nausea, the stomach's normal rhythm and downward movement becomes

[06:38]

disrupted, while the brain and nervous system activates protective signals to slow the digestion

[06:45]

and prepare the body to reject or to avoid a perceived threat. In traditional Chinese medicine,

[06:51]

the perspective converges. In Chinese, there's a saying, and the saying goes like this,

[06:58]

when the stomach energy rebels upward, the head suffers. Yes, these guys have a saying for what

[07:05]

you feel so often, like there's a sentence for it. If you know me a little, you will know that

[07:10]

I love languages and travel. And so I've learned many languages in my life, about seven, and

[07:16]

Mandarin is one of them. And I find languages so revealing of a culture and so many other

[07:20]

learnings, and Mandarin is definitely one of them when it comes to Mandarin. In Chinese medicine,

[07:25]

the stomach is meant to send energy downward, calmly, smoothly, like a river flowing toward

[07:33]

the sea. But modern life often pulls us upward instead. We rush, we multitask, we ease while

[07:40]

answering emails, driving, scrolling, worrying. We live in a constant state of stimulation, and over time,

[07:46]

the body can lose its natural rhythm. And what Chinese medicine calls rebellious stomach qi is

[07:52]

when that downward flow reverses direction. Instead of grounding, the energy rises upward, showing up

[07:57]

as reflux, nausea, burping, tightness, or even, of course, headaches and migraines. It's fascinating

[08:03]

because the causes are often deeply human. Stress, overthinking, emotional tension, eating too quickly,

[08:09]

skipping meals, too much coffee, too little rest, not enough presence. And migraine and nausea are

[08:14]

not viewed as isolated symptoms. They are seen as signs as the body's internal energies are

[08:18]

struggling to move harmoniously. From an Eastern perspective, the body's not malfunctioning

[08:23]

randomly. It's trying to communicate imbalance. And in a more fundamental way, the stomach doesn't

[08:29]

just digest food, it digests life. And when life becomes too rushed, pressured, cold, irregular, or

[08:35]

emotionally overwhelming, or intoxicated with recreational and non-recreational toxins, the body

[08:42]

begins to rebel against the pace we're asking it to keep. Ayurveda, so the Indian traditions, offer

[08:48]

another interesting lens. In Ayurvedic medicine, migraines with nausea are linked often to the

[08:53]

imbalances of pitta and vata. And pitta relates to heat, intensity, inflammation, overdrive. And vata

[09:00]

relates to movement, the nervous system, instability, hypersensitivity. And so when

[09:05]

both become aggravated, symptoms such as throbbing headache, nausea, digestive upset, may merge

[09:11]

together. Eastern medicine often focuses less on suppressing symptoms and more on restoring rhythm.

[09:18]

Warm cooked foods, gentle routines, calming the nervous system, reducing overstimulation,

[09:24]

supporting digestion before forcing productivity. There's also a deep respect for the emotional

[09:30]

dimension of illness. In many Eastern traditions, digestion is not just about food, it's also about

[09:36]

what you are emotionally trying to process. And sometimes migraines appear when the body feels

[09:41]

overloaded, physically, emotionally, mentally, or energetically. So rather than asking

[09:47]

what is wrong with me, Eastern philosophy gently asks, what is my body trying to tell me?

[09:52]

That shift alone can change the entire healing journey. So what can you do today from your home?

[09:57]

Today, I'd like you to try this simple gut brain calming ritual at home. When nausea or migraine

[10:02]

symptoms begin, sit somewhere quiet and place one hand on your chest, one hand on your stomach,

[10:08]

and slowly inhale through your nose for four seconds, exhale for six seconds, for two minutes.

[10:14]

Then chew, if you have nausea and migraines often, keep them in your fridge. Chew some candied ginger

[10:19]

slowly, no ice cold, no ice drinks, avoid screen and harsh light for just 10 minutes if possible.

[10:28]

And this combination can help activate your vagus nerve, calm your nervous system, and support

[10:33]

digestion gently instead of forcing your body into more stress. Small signals of safety can

[10:39]

sometimes interrupt the migraine spiral earlier than you think. And by no stretch of imagination

[10:44]

am I saying things are that simple. Sometimes, and maybe for your profile, things are incredibly

[10:50]

complex and incredibly difficult. And if that's you, then search for this podcast and then search

[10:56]

in our podcast for other keywords beyond nausea, what else is happening, so you can rebuild a whole

[11:02]

mental picture of what's happening in your body and have lots of these small advice that help you

[11:08]

make the right decisions and more and more better decisions that allow you to regain control.

[11:14]

And remember, every small step you take moves you closer to freedom. You are powerful,

[11:21]

you are resilient, and you're not alone. Keep rising, Migraine Hero.

Originally published June 2026

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