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Blood Sugar and Migraines: The Hidden Energy Crash Behind Your Pain
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Blood Sugar and Migraines: The Hidden Energy Crash Behind Your Pain

12 min

00:00
-12:00

What if your migraine isn’t just about what you eat but about when your energy crashes?

In this episode of Migraine Heroes Podcast, Diane Ducarme uncovers the powerful link between blood sugar and migraines—and why even “normal” labs can miss what your brain is truly experiencing.

Your brain is one of the most energy-demanding organs in your body. When blood sugar drops, it can trigger a silent alarm that destabilizes your nervous system and opens the door to pain.

You’ll discover: 💡 Why sudden blood sugar dips can trigger migraines even when everything looks fine on paper 💡 How your brain’s high energy demands make it especially sensitive to glucose fluctuations 💡 A simple, practical way to stabilize your blood sugar and create a safer, steadier environment for your brain

This episode helps you move beyond surface-level advice and understand the deeper energy dynamics behind your migraines so you can support your brain with consistency, not guesswork. 

🎧 New episodes every Monday and Wednesday 🔗 Discover our work on migraineheroes.com

**References: **

  • Pathophysiology of Migraine (Goadsby et al., 2017): This major review explains migraine as a disorder of sensory processing, covering trigeminovascular mechanisms, aura, genetics, and brain network dysfunction.Read more here.
  • Diet and Headache: Part 1 (Martin & Vij, 2016): This review examines how foods, food components, and elimination diets may influence headache and migraine, including evidence around caffeine, MSG, alcohol, and other dietary triggers. Read more here.
  • Magnetic Resonance Spectroscopy Studies in Migraine (Montagna, Cortelli & Barbiroli, 1994): This review looks at magnetic resonance spectroscopy findings in migraine and discusses abnormal brain and muscle energy metabolism as a possible part of migraine biology. Read more here.
  • Migraine Triggers: Practice and Theory (Blau, 1992): This paper questions simplistic ideas about migraine triggers and argues for a more careful interpretation of how triggers may lower the threshold for an attack rather than directly cause one. Read more here.

Disclaimer: This podcast is for informational purposes only and does not substitute for providing medical advice. Always consult your healthcare professional before making any health-related decisions. For women, men, and children who suffer from migraine disease, Migraine Heroes is your go-to resource for understanding, managing, and overcoming migraine attacks. We cover all types of migraines and related headaches, including primary and secondary migraines, chronic migraines, and cluster migraines. We dive deep into the complexities of migraine with aura and migraine without aura, as well as rarer forms like hemiplegic migraine, retinal migraine, and acephalgic migraine (silent migraine). Our discussions also extend to cervicogenic headaches, ice pick headaches, and pressure headaches, which often mimic migraine or contribute to overall migraine burden.

Transcript

[00:00]

What if some of your migraines were not random at all, but your brain desperately reacting

[00:06]

to unstable blood sugar?

[00:11]

Welcome to Migraine Heroes, a podcast for people living with chronic migraines with

[00:15]

years of pain, misunderstanding, and lack of answers.

[00:20]

I'm Diane Ducarme.

[00:21]

I've helped more than a thousand people reduce the burden of migraines and feel more in control.

[00:27]

My mission in life, to help a million people.

[00:31]

Each episode brings you grounded insight into what your body might be asking for and what

[00:36]

can truly help.

[00:38]

Just to keep you fully supported, this podcast is educational.

[00:43]

For diagnosis or medication, always work with your doctor.

[00:48]

Now take a breath and let's dive in.

[00:56]

In this episode, you will learn why sudden drops in blood sugar can act as a powerful

[01:00]

migraine trigger, even if your blood tests look normal, how your brain's massive energy

[01:06]

needs make it especially vulnerable to blood sugar swings, and a simple way to stabilize

[01:12]

your blood sugar so your brain feels safer and migraines may happen less often.

[01:18]

Stay with me till the end because you will learn a simple way to structure your meals

[01:23]

that can stabilize your brain's energy and potentially prevent migraines before they

[01:27]

even begin.

[01:29]

If you live with migraines, you may know the feeling, the sudden irritability, the fatigue,

[01:35]

the brain fog, and then the headache begins to build.

[01:39]

And you may have asked yourself, did I eat enough today?

[01:42]

Did I wait too long between meals?

[01:45]

Why does skipping one meal seem to punish my brain so severely?

[01:49]

And if that sounds familiar, you're not imagining it.

[01:53]

Many migraine patients report that fasting or skipping meals or energy crashes are among

[01:59]

their strongest triggers.

[02:02]

So let us start with the basics.

[02:03]

Blood sugar, also called glucose, is the primary fuel circulating in your bloodstream.

[02:11]

Every cell in your body uses glucose for energy, but your brain depends on it more than almost

[02:19]

any other organ.

[02:20]

And despite representing only about 2% of your body's weight, your brain consumes roughly

[02:25]

20% of your body's energy supply.

[02:29]

And so when blood glucose levels drop too low, the brain experiences what scientists

[02:34]

sometimes call neuroglycopenia, meaning a shortage of glucose for brain function.

[02:41]

Symptoms may include fatigue, dizziness, irritability, confusion, and importantly for migraine sufferers,

[02:48]

headaches.

[02:49]

Research has increasingly shown that migraines may involve, in some cases, a brain energy

[02:55]

deficit.

[02:56]

A landmark paper by Dr. Goadsby, published in the journal Nature Reviews Neurology, describes

[03:04]

migraine as a disorder of brain excitability and metabolic vulnerability.

[03:09]

In other words, the migraine brain may struggle to produce or regulate energy efficiently.

[03:15]

By the way, each time we mention papers here, they're all in the show notes below.

[03:19]

So this means that when blood sugar levels fluctuate dramatically, especially when they

[03:25]

drop suddenly, the brain may enter in a state of metabolic stress that then can trigger

[03:33]

a migraine attack.

[03:34]

Another study published in the journal of Headache and Pain examined common migraine

[03:39]

triggers and found that fasting and irregular meals were among the most frequently reported

[03:44]

triggers, particularly in people with chronic migraine.

[03:48]

But the story goes deeper.

[03:51]

Research suggests that migraine patients may also have mitochondrial dysfunction.

[03:57]

Mitochondria are the tiny power plants inside your cells that convert nutrients into usable

[04:02]

energy.

[04:03]

When mitochondrial efficiency is lower, the brain becomes more sensitive to any interruption

[04:09]

in energy supply.

[04:11]

And a study in Neurology proposed that migraines may arise when the brain's energy demand

[04:16]

temporarily exceeds its energy production capacity.

[04:20]

So now imagine what happens when someone skips breakfast, drinks coffee instead of eating,

[04:26]

or goes six hours without food, or, like I sometimes have, starts to exercise on an empty

[04:32]

stomach.

[04:33]

The brain's sugar levels may fall.

[04:35]

The body releases stress hormones like adrenaline and cortisol to compensate, and these hormones

[04:41]

then can increase inflammation, alter blood vessel behavior, and stimulate nerve pathways

[04:46]

involved in migraine.

[04:47]

In other words, a simple energy shortage may ignite a complex neurological cascade.

[04:54]

Scientists also suspect involvement of the hypothalamus, a region of the brain responsible

[04:58]

for regulating hunger, metabolism, and circadian rhythms.

[05:02]

Imaging studies have shown that the hypothalamus becomes active hours before a migraine attack

[05:08]

begins, suggesting that a metabolic imbalance could be part of the trigger process.

[05:15]

So the emerging picture from Western science is this.

[05:20]

Migraines are not simply headaches. They may represent a brain struggling to maintain a

[05:24]

stable energy in an unstable metabolic environment.

[05:29]

And blood sugar swings, even really subtle ones, may push the brain over its threshold.

[05:35]

And by the way, that's the truth for all human beings.

[05:39]

Now I'm a mom, right?

[05:40]

And as a person, you know, who can suddenly sometimes have crashes of energy, or just

[05:46]

having children who are constantly suggested sweets in Ubers and in airplanes, and just

[05:56]

the daily lives that they are surrounded by sweet stuff for birthdays, etc.

[06:02]

They know I'm trying not to be overly saying no, that's really hard, really, really hard.

[06:06]

But I ask of them that they don't have things on an empty stomach.

[06:10]

And so that if they want an indulgence, it's better they put it in their pocket and have

[06:14]

it after lunch, which is a great time, but not sort of mid-morning on an empty stomach.

[06:19]

Now let's go east for a minute.

[06:21]

Traditional Chinese medicine has observed something fascinating about headaches for

[06:25]

more than 2,000 years.

[06:27]

The brain is deeply connected to nourishment and flow of energy from digestion.

[06:32]

In traditional Chinese medicine, the digestive system is governed primarily by a system you

[06:38]

sometimes hear me talk about, which is the stomach spleen system.

[06:42]

So the system is actually responsible for transforming your food into energy, so into

[06:48]

qi, and into blood, into matter.

[06:51]

And those are vital substances that are going to nourish the entire body, including that

[06:57]

voracious brain.

[06:58]

There's an old saying in Chinese, the spleen is the source of post-natal energy.

[07:05]

皮是后天织本。

[07:08]

If you had to translate it literally, it would mean, 皮, which is the stomach spleen, 是,

[07:13]

which is, is, 后天, is the day after tomorrow, 织本, is the foundation.

[07:20]

So the stomach spleen is the foundation of the day after tomorrow.

[07:24]

So after you're born, you're born with your mom's essence and your father's contribution.

[07:29]

But then to sustain yourself, you're going to eat the food and transform it.

[07:34]

So what does it concretely mean?

[07:36]

It means that after you were born, your vitality is going to depend largely on how well you

[07:43]

transform your food into usable energy.

[07:46]

This is something that the West completely misses, and it drives me insane.

[07:50]

We talk a lot about calories and how many calories we put in, and therefore how much

[07:54]

energy can we put out.

[07:56]

But that also poses a strong stomach spleen.

[08:00]

If that function is weak, what you put in and what you get out is an equation that doesn't

[08:05]

really compute.

[08:07]

When your spleen system is strong, your energy is going to be produced smoothly, blood is

[08:13]

going to circulate well, and your head, your brain, is going to be nourished.

[08:18]

But when your spleen becomes weakened through irregular meals, excessive sugar, chronic

[08:23]

stress or eating too quickly, your blood is going to struggle to transform that food efficiently.

[08:30]

And in traditional Chinese medicine terms, this is going to lead to deficiencies.

[08:34]

When your brain does not receive steady nourishment, symptoms may appear such as headache, dizziness,

[08:41]

but also fatigue, that mental fog, and sensitivity to light and to sound or to smell.

[08:47]

Does that sound familiar?

[08:49]

Interestingly, many classical texts also warn against skipping meals or eating at regular

[08:55]

times, which social media these days can completely promote.

[08:59]

Regular meals help the digestive organs maintain rhythm.

[09:04]

Irregular eating disrupts the transformation of energy.

[09:07]

Ayurveda shares a completely similar perspective.

[09:10]

In Ayurvedic medicine, digestion is governed by acne, that digestive fire.

[09:15]

And when meals are skipped or digestion becomes unstable, acne weakens.

[09:20]

This can create a Vata imbalance, which is strongly associated with headaches, nervous

[09:24]

system instability, and sensitivity.

[09:26]

Both Eastern traditions, therefore, emphasize something that modern science is not rediscovering.

[09:32]

The brain suffers when nourishment becomes irregular.

[09:36]

Margarine, in this view, is not just a neurological event,

[09:39]

it's also a signal that the body's energy rhythms have been disrupted.

[09:44]

And sugar does that beautifully with sugar crashes.

[09:47]

And sugar does that atrociously well with sugar spikes and crashes.

[09:52]

Restoring rhythm in meals, sleep, and digestion helps restore stability to the mind.

[09:58]

Now, I want to insist that if this is you every single day, if you're in pain every

[10:03]

single day, this is one small piece of a much, much, much larger and more complex puzzle.

[10:09]

However, it's a very important one, especially as when you're in pain every single day, you

[10:14]

may start to have sort of what I would call a margarine jet lag, where because you're

[10:18]

a bit rigid all day, your days become your nights, etc. and your whole body clock becomes

[10:24]

very confused.

[10:25]

Now, here's something very simple you can try today at home.

[10:28]

So for the next week, experiment with a blood sugar stabilizing meal rhythm.

[10:33]

Eat within an hour of waking up.

[10:36]

By the way, the best time to eat for the stomach spin is 7am to 9am.

[10:40]

If you can make that window, please do so.

[10:44]

Do not wait longer than four hours between meals.

[10:47]

And at every meal, include protein, and try to start with those, healthy fat, and slow

[10:53]

carbohydrates. So

[10:54]

for example, eggs with avocado and a whole grain toast, or chicken with vegetables and

[11:00]

rice.

[11:01]

And if possible, consume those in that order.

[11:04]

In restaurants, they do something very tricky,

[11:06]

they put bread on the table, and you might think that this is offered free of charge,

[11:11]

and what does the restaurant have to gain with that, given they start to fill your belly

[11:15]

before you started eating.

[11:16]

Actually, if you start with the carbohydrates, like bread, you're going to have a sugar crash

[11:21]

right at the time of your dessert,

[11:23]

and so just in time to expand that bill a little and expand that appetite very much.

[11:29]

Now if you eat with that combination, it's going to help slow glucose release into the

[11:34]

bloodstream, preventing sudden spikes and crashes that may stress your brain.

[11:39]

If you do want to indulge, do so after a full meal, just like in my household.

[11:46]

And remember, every small step you take moves you closer to freedom.

[11:51]

You are powerful, you are resilient, and you are not alone.

[11:56]

Keep rising, Migrant Hero.

Originally published May 2026

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