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3 Food Chemicals That Could Be Triggering Your Migraine (And How to Eliminate Them)
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3 Food Chemicals That Could Be Triggering Your Migraine (And How to Eliminate Them)

9 min

You eat clean and hydrate—so why migraines? This episode uncovers hidden food chemicals silently fueling your attacks.

00:00
-09:00

You eat clean. You hydrate. You do everything “right.”

So why do your migraines keep coming back?

In this episode of The Migraine Heroes Podcast, we dig into a hidden piece of the puzzle: common food chemicals that may be silently triggering your attacks—even from foods you thought were healthy.

Hosted by Diane Ducarme, founder of Migraine Heroes and passionate advocate for functional healing, this podcast blends neuroscience, Eastern wisdom, and lived experience to give you relief that actually lasts.

This week, we’ll uncover: ● The top 3 food chemicals linked to migraine flare-ups: nitrates, MSG, and tyramine ● How they affect your blood vessels, nervous system, and inflammation levels ● The surprising Eastern medicine interpretation of these compounds—how they disturb your body’s energetic balance ● Practical ways to track, test, and tailor your diet without going into restriction mode

💡 Plus: Why your body might be overreacting not because it's broken, but because it’s incredibly sensitive—and how to use that sensitivity as a superpower.

Whether you're navigating mystery migraines or fine-tuning your diet for fewer flare-ups, this episode will help you reconnect the dots between what’s on your plate and what’s happening in your brain.

🎧 Tune in every Monday and Wednesday for science-backed, soul-nourishing episodes that go beyond surface-level solutions.

Transcript

[00:00]

Are everyday foods secretly fueling your migraines?

[00:04]

This episode unpacks the hidden chemicals

[00:06]

that may be behind your worst attacks

[00:09]

and what to do about them.

[00:14]

Migraine Heroes is a podcast for chronic migraine sufferers

[00:17]

who've seen countless doctors with no results.

[00:22]

Learn how to reduce your migraine attacks

[00:24]

without endless medications or constant sacrifices.

[00:28]

Hello, I'm Diane Ducarme.

[00:30]

I've helped over 500 people break free from migraine,

[00:33]

even after suffering for up to 60 years.

[00:37]

My mission in life?

[00:38]

To bring this relief to a million people

[00:40]

using a unique blend of Eastern medicine

[00:43]

and Western science.

[00:48]

In this episode, you will learn

[00:49]

the top three food chemicals

[00:51]

most commonly linked to migraine attacks,

[00:54]

why your favorite healthy foods

[00:56]

might be setting off your symptoms

[00:58]

and how to identify and safely eliminate these chemicals

[01:02]

from your diet starting today.

[01:05]

Stay with me until the end

[01:06]

because we'll also explore

[01:07]

what traditional Chinese medicine says about food chemicals

[01:11]

and it's surprisingly empowering.

[01:14]

Now let's begin with the Western perspective

[01:16]

on food chemicals and migraines.

[01:19]

So food chemicals are substances

[01:21]

either naturally occurring or adding during processing

[01:25]

that can have psychological effects.

[01:28]

While many are safe for the general population

[01:31]

or at least considered to be safe,

[01:34]

for migraine sufferers, they may act as potent triggers.

[01:39]

A study published in Neurology

[01:41]

reported that up to 30% of migraine sufferers

[01:44]

identified food as a significant trigger,

[01:47]

but what exactly in the food?

[01:50]

It's not always the food itself.

[01:52]

It's often what is in the food, inside the food.

[01:56]

So chemical culprits number one, nitrates and nitrates.

[02:02]

These are commonly added to processed meats

[02:05]

to preserve color and prevent bacterial growth.

[02:09]

A groundbreaking 2017 study in M Systems

[02:13]

found that people who suffer from migraine

[02:15]

have a higher level of nitrate-reducing bacteria

[02:19]

in their mouths.

[02:20]

This suggests a metabolic compound

[02:22]

where nitrates may be more readily converted

[02:25]

into nitric oxide, a known migraine trigger.

[02:30]

Nitric oxide is a vasodilator.

[02:32]

It causes blood vessels to widen.

[02:35]

While this can improve circulation,

[02:37]

in migraine-prone individuals,

[02:39]

the sudden dilation can activate pain pathways in the brain,

[02:42]

especially around the trigeminal nerve,

[02:45]

which is central to migraine attacks.

[02:47]

And what's more, nitric oxide can trigger

[02:50]

the release of inflammatory molecules like the CGRP,

[02:55]

the calcitonin gene-related peptides.

[02:59]

CGRP plays a major role in migraines

[03:02]

by widening blood vessels even more,

[03:04]

increasing inflammation, heightening pain sensitivity.

[03:08]

Nitric oxide can also raise the excitability

[03:11]

of neurons of your brain cells.

[03:13]

In people with migraine,

[03:14]

the brain is already more sensitive or hyper-excitable,

[03:18]

so too much nitric oxide can cause a kind of chain reaction

[03:23]

leading to the start of a migraine aura or pain phase.

[03:27]

Chemical culprit number two, monosodium glutamate, or MSG.

[03:33]

You've probably heard of MSG,

[03:34]

the flavor enhancer found in many savory or processed foods.

[03:39]

But did you know it could be triggering your migraines?

[03:42]

MSG is often blamed

[03:43]

for the so-called Chinese restaurant syndrome.

[03:46]

MSG is a form of glutamate, a natural chemical in your brain

[03:50]

that excites neurons and helps them communicate.

[03:53]

But for those of us with migraine-prone brains,

[03:57]

which are already more sensitive,

[03:59]

too much glutamate can overstimulate the nervous system.

[04:02]

This surge can cause neurons to fire excessively,

[04:06]

setting off a cascade of symptoms like throbbing pain,

[04:09]

dizziness, nausea, or even aura.

[04:13]

On top of that,

[04:14]

excess glutamate can spark inflammation

[04:16]

and disrupt blood flow,

[04:17]

two major things that can make migraine worse.

[04:20]

So if you feel off after a takeout meal or a salty snack,

[04:25]

MSG might be part of that story.

[04:29]

A 2018 review in Nutrients

[04:31]

confirms that MSG can cause headache

[04:33]

in susceptible individuals,

[04:35]

possibly by exciting certain neurons in the brain

[04:38]

and altering the glutamate's pathway.

[04:40]

Now, I have lived for five years in Shanghai

[04:43]

and I lived in Beijing and Xi'an as well.

[04:46]

I love Asian foods.

[04:48]

I really, really, really do.

[04:50]

However, over the last years,

[04:51]

I have personally developed an intolerance to MSG.

[04:54]

MSG in the food, I know it within the hour.

[04:57]

The weight manifests for me is just really intense thirst.

[05:01]

I'm gonna be due to bedtime and compulsively drinking water.

[05:05]

And then I know I'm gonna wake up

[05:07]

and just suddenly from one to 3 a.m.

[05:09]

when my liver is detoxing.

[05:11]

And so basically I'm on a sort of no MSG couple of months

[05:14]

to desensitize myself

[05:16]

because I can really feel it's getting at me.

[05:19]

Chemical culprit number three, tyramine.

[05:23]

Tyramine is a naturally-occurring compound

[05:25]

found in aged, fermented, or cured foods

[05:28]

like aged cheeses, smoked meats, and soy products.

[05:32]

And according to a 2016 article

[05:35]

in the Journal of Headache and Pain,

[05:37]

tyramine can influence blood vessel dilation

[05:39]

and affect neurotransmitter balance,

[05:41]

both key factors in migraine onset.

[05:44]

So the overarching hypothesis is that these chemicals

[05:49]

either directly affect the brain's pathways,

[05:52]

alter vascular function, visodilation,

[05:55]

cause inflammatory responses,

[05:57]

or influence or end influence the gut-brain axis.

[06:02]

Now let's turn east for a minute

[06:04]

and go to traditional Chinese medicine.

[06:06]

Traditional Chinese medicine views food

[06:08]

not just as a collection of chemicals,

[06:10]

but it looks at food the way it enters the body,

[06:13]

and it looks at it as energetic medicine.

[06:16]

And so for them, nitrates and nitrates

[06:18]

would be seen as toxic dampness contributors.

[06:21]

Processed meats are damp-producing

[06:24]

and difficult to digest,

[06:25]

clouding clarity of the shen, the spirit,

[06:28]

and disturbing some of the stomach's pain axis.

[06:31]

If we take MSG, it's gonna excite the nervous system.

[06:35]

In traditional Chinese medicine,

[06:36]

this could be interpreted as creating internal wind

[06:40]

and disturbing the harmony of the heart and of the liver,

[06:43]

leading to agitation and headache.

[06:45]

And the tyramine-rich foods

[06:47]

are often characterized as yang excess food.

[06:50]

They create internal heat, disturb the liver,

[06:53]

which in traditional Chinese medicine

[06:55]

governs the free flow of qi and blood,

[06:57]

and so liver-qi stagnation can lead

[06:59]

to what is called liver yang rising,

[07:02]

which is frequently implicated in migraine headaches.

[07:05]

Now, additionally, Ayurveda emphasizes the concept of ama,

[07:10]

or toxic buildup due to improper digestion.

[07:14]

All three chemicals mentioned are seen to create ama,

[07:17]

leading to blockages and disease.

[07:20]

In traditional Chinese medicine, that term is called tan.

[07:23]

So your brain is right to complain about them.

[07:26]

They should be avoided by all,

[07:29]

not just by people suffering from migraine.

[07:31]

In the Migraine Heroes app,

[07:33]

we put your triggers in a customized way,

[07:36]

not because you should not have them.

[07:37]

You can always have them,

[07:38]

but because having them too frequently

[07:40]

or not knowing that they actually harm you

[07:42]

can slow down your recovery process.

[07:44]

You should only have them

[07:45]

if you're craving them at all costs,

[07:47]

or if you really like them,

[07:49]

but you shouldn't have them

[07:50]

because they're part of your routine, is what I'm saying.

[07:53]

So that's why it's so important to cook your own foods

[07:57]

and know what you're eating.

[07:59]

If your brain is highly sensitive,

[08:01]

as it often is with migraines,

[08:03]

then what you put in your body matters deeply.

[08:06]

Substances like MSG might be invisible to your eyes,

[08:10]

but they're definitely not invisible to your brain.

[08:13]

So support your nervous system

[08:15]

by making intentional choices.

[08:17]

Cook from scratch when you can,

[08:19]

choose whole foods,

[08:20]

and treat your brain like the powerhouse it is.

[08:22]

It's listening to everything you feed it.

[08:26]

And remember, every small step you take

[08:29]

moves you closer to freedom.

[08:31]

You are powerful, you are resilient,

[08:34]

and you are no longer alone.

[08:35]

Keep rising, migraine hero.

Originally published June 2025

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