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What if the migraines that suddenly feel more frequent, more intense, and less predictable
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are not random at all, but your brain responding to one of the most hormonally turbulent transitions
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Welcome to Migraine Heroes, a podcast for people living with chronic migraines with
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years of pain, misunderstanding, and lack of answers.
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I'm Diane Ducarme.
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I've helped more than a thousand people reduce the burden of migraines and feel more in control.
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My mission in life?
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To help a million people.
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Each episode brings you grounded insight into what your body might be asking for and what
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Just to keep you fully supported, this podcast is educational.
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For diagnosis or medication, always work with your doctor.
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Now take a breath and let's dive in.
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In this episode, you will learn why hormonal instability matters more than simply having
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low hormones and why the ups and downs of estrogen may make your migraine brain much
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Why symptoms such as poor sleep, hot flashes, anxiety, irregular periods, and migraine can
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become tangled together, creating what can feel a vicious cycle.
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A simple strategy you can start at home today to identify your personal rhythm and make
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this phase of life a little less unpredictable.
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Stay with me till the end because at the end of this episode, you will have a simple way
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to start separating what you cannot control, your hormonal transition, from several things
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you may actually be able to influence.
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So if you're in your 40s or early 50s and thinking, what is happening to me?
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My migraines used to make sense or that word was estranged to me before and now they are
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taking over my life.
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And I want to acknowledge how unsettling that can feel.
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So perhaps you had migraines once or twice a month and suddenly they're appearing every
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week or even worse, every single day.
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Perhaps your medication and other coping mechanisms do not seem to work anymore in the same way.
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Perhaps your period comes after 24 days one month, 38 days the next, and then disappear
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You may sort of sleep badly.
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You may wake up hot, 3 a.m. sharp in the morning, eyes wide open.
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You may feel more irritable or more emotionally sensitive, really on edge.
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And on top of all of that comes a migraine.
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It can feel as though your body has changed the rules without telling you.
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Your body and brain were completely betraying you.
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And this all comes at a time when your children are leaving the nest but still fundamentally
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need you, at a time when your partner is also going through their head changes, at
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a time when your parents need you the most, or when you have the highest responsibilities
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at work, at a time when you're contributing to your community, and it can feel completely
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It's like you've lost your superpowers and you're kind of losing yourself.
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I remember this woman, when we met, she said to me, you know, it's not that I'm suicidal
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I have a husband, I have children, grandchildren.
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In many ways, these are golden years.
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But when I go to bed, I really think to myself, if I don't wake up tomorrow, really, it doesn't
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It's just so hard.
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And so there is a biological reason why the spirit can be particularly difficult for someone
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So I want to talk today about perimenopause and first going to very briefly define it.
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So perimenopause is the natural biological transition leading up to menopause, when the
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body gradually produces less estrogen and menstrual cycles begin to change.
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So it's often identified by persistent difference of seven days or more in cycle length and
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maybe accompanied by symptoms such as hot flashes, sleep disruption, or mood changes.
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Perimenopause is defined primarily by changes in the menstrual cycles rather than a single
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blood test and continues until one year after the final menstruation period, in which case
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we enter menopause.
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During this transition, estrogen does not simply move gently downward in a straight
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It can rise, it can fall, it can surge and fall again.
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And that distinction matters enormously for migraine.
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Because for migraine brains, the problem appears to be less about one specific estrogen level
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and more about rapid hormonal changes.
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So in the journal called Maturitas, researchers describe perimenopause as a period associated
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with increased migraine, so particularly menstrual migraine, and highlighted unpredictable
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estrogen fluctuations as an important contributor.
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So this was in 2020.
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So more recent reviews have reached sort of similar conclusion.
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In 2026, there was a review in Headache, and it was saying that unstable estrogen and progesterone
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during perimenopause were described as factors that can worsen both the frequency and predictability
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of migraine attacks.
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So when someone tells you your hormones are normal, they may not tell you the entire story.
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A blood test, for example, is a single photograph, while perimenopause is a changing landscape
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and migraine may be reacting to the shifts happening between pictures.
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So there's a huge estrogen withdrawal hypothesis in all of that.
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So one of the famous explanations for hormonally associated migraine during perimenopause is
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called the estrogen withdrawal hypothesis.
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So one of the famous explanations for hormonally associated migraine is called the estrogen
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withdrawal hypothesis.
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And so the idea is that sufficiently rapid decline in estrogen can lower the threshold
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at which the nervous system generates a migraine attack.
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This is one reason migraine attacks often cluster around menstruation.
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But there's an important scientific nuance here.
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Although estrogen withdrawal is widely accepted as a plausible trigger, it has not been conclusively
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proven to explain every menstrual or perimenopausal migraine.
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And I would completely agree with that.
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The nuance is important.
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We do not need to replace one oversimplification with another.
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It's not like estrogen goes down, therefore migraine happens.
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So your brain is not separate from your hormones.
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So estrogen receptors are found in areas involved in pain processing and reproductive hormones
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and interact with the trigeminovascular system, the network of nerves and blood vessels deeply
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involved in migraine biology.
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Researchers have also become increasingly interested in the relationship between estrogen
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and other signaling molecules involved in migraine.
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So think of your migraine threshold almost like a glass.
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So your genetic predisposition is going to make the glass in the first place.
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Then hormonal fluctuations will add some water, and then poor sleep will add, and stress will
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Skipping lunch adds some, dehydration adds some, hot flashes add some, and then one day
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the glass spills over.
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And so the migraine may appear to have been triggered by one thing, but biologically,
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it may have been the sum of several pressures arriving at the same time.
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And so this brings us to something extremely important about perimenopause, is that the
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hormone change is only part of the story, because perimenopause can affect so much more
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than menstruation.
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Sleep fragments, night sweats can wake you repeatedly, mood and anxiety symptoms may
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change, your body temperature regulation changes, menstrual bleeding may become heavier, energy
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can fluctuate, and each of these can potentially interact with migraine vulnerability.
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That is why treating perimenopausal migraine as simply a headache problem can completely
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miss the big picture.
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So there was a 2026 review by Friedman, Korn and Bernstein that emphasized this interaction,
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noting that sleep disturbance, vasomotor symptoms, mood disorders, and metabolic changes
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can complicate migraine management during midlife.
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So imagine someone who already has a sensitive migraine nervous system.
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She begins sleeping five fragmented hours instead of seven, she wakes sweating several
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times each night, her menstrual cycle becomes unpredictable, she's exhausted, so she skips
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breakfast, she increases caffeine just to function, her stress tolerance falls, and
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then she experiences more migraine attacks.
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So was it oestrogen?
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Yes, perhaps, partly.
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Was it all those systems interacting?
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Well, very possibly.
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That's why I prefer to think of perimenopause creating a period of reduced neurological margin
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Your nervous system may simply have less room to absorb disruption.
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So how big is this effect?
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Are you alone in this?
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So the increase is large enough to be measurable at a population level.
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There was a study of 3,664 women with migraine, which was published in Headache in 2016, and
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8% of premenopausal women experienced high frequency headaches, so defined as 10 or more
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headaches days per month.
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And during perimenopause, that rose to 12.2%.
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So put in another way, the proportion of women experiencing frequent headaches was
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about 50% higher during perimenopause.
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It's a massive increase.
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So even after researchers accounted for factors such as age, depression, body mass index,
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preventative medication use, and medication overuse, women in perimenopause still had
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42% higher odds of high frequency headache than premenopausal women.
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So this is not simply anecdotal.
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Perimenopause is a recognized period of increased migraine vulnerability.
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It does not mean that every woman's migraine will worsen, but for a meaningful subgroup,
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the transition can push migraine from an occasional problem toward a much more frequent one.
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So I want to talk about why menstrual migraine can become especially difficult.
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So if you already experienced migraine around your period before perimenopause, this transition
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it may become particularly challenging.
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During a predictable reproductive cycle, you might at least have known my period is coming
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Tuesday and my migraine usually starts on Monday or even maybe on Sunday.
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But perimenopause can move that predictability.
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Ovulation becomes less consistent, cycle length changes, and hormonal peaks and declines become
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And so migraine attacks can appear to move around the calendar.
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So a 2026 narrative review of perimenopausal migraine described early perimenopause as
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a phase in which high and fluctuating estrogen, shorter cycles, and more frequent anovulatory
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cycles may contribute to increased migraine severity and more perimenstrual attacks.
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So if your old migraine calendar suddenly seems useless, there may be a reason.
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The rhythm itself is changing.
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Now what about menopause?
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Does it ever get better?
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And so there's some encouraging news.
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So for many women, particularly those with migraine without aura, migraine tends to improve
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after natural menopause, once the hormonal turbulence finally settles.
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And notice the word settles.
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Again, stability may matter.
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During perimenopause, the hormones fluctuate dramatically.
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After menopause, estrogen remains much lower, but generally becomes more stable.
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Migraine does not disappear in everyone, and people with chronic migraine may continue
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having substantial symptoms, but several reviews describe improvement after spontaneous menopause
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for a significant proportion of women.
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So in other words, perimenopause can sometimes be the storm before calmer hormonal weather.
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So I'm reminded of a woman I met in New Zealand.
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It was around 2019, maybe 2020 maximum, and she had been told that her migraines would
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improve when she reached menopause.
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And she was so desperate for relief that she underwent artificial menopause.
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So she underwent surgery to remove her uterus and her ovaries in the hope of decreasing
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And then we worked together and we achieved that.
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That case stayed with me because it showed me how far people are willing to go to escape
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migraine and how desperate and vulnerable they are.
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And so I always add a word of caution when we talk about averages and statistics, which
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You're not a statistic, you know, you are a hundred percent of yourself.
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And so being told to simply wait for the storm to pass can be incredibly painful when that
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promise never comes.
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What about menopausal hormone therapy?
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So this is where individualized medical care becomes extremely important and really professional
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There's no universal rule saying menopausal hormone therapy cures migraine or causes migraine.
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Its effects vary, quite honestly.
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Delivery methods matters.
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Whether hormones are continuous or cyclical matters.
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And whether you are having migraine with or without matters.
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Your cardiovascular risk factors matter.
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And the reason you are considering hormone treatment matters.
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Current reviews generally suggest that when menopausal hormone therapy is appropriate,
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maintaining more stable hormone exposure may be better tolerated by some people with migraine
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than producing repeated hormonal peaks and troughs.
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Transdermal estrogen, therefore estrogen delivered through the skin, is often discussed
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a bit more because it can provide a steadier hormone level than some oral regimens.
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But this is absolutely an area to discuss with a clinician who understands both menopause
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and migraine, particularly if you experience migraine with aura or have cardiovascular
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Migraine with aura carries additional vascular considerations, so hormonal decisions should
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never be based just on a podcast or what worked for a friend.
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Migraine is complex, it's not random, but you are unique.
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And look, I've seen hormone therapy do wonders for some women, sometimes completely changing
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their quality of life, but also sometimes creating much, much damage.
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And so, so much depends on finding the right type and the right dose for you.
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And also, remember what worked beautifully a couple of years ago may need a solid adjustment
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So try to keep the dialogue open with your clinician and report anything that feels wrong.
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Also, please consult with people who really know what they're talking about hormone-wise.
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This is not a standard training for all doctors, so try to find people who are really specialized
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Now, as you listen, I am well aware that for some of you, even getting one appointment
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That can feel frustrating and infuriating and unfair.
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So that will be the object of another podcast.
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I'm really conscious.
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It can be really problematic.
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Now let's turn east.
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Traditional Chinese medicine is going to look at this period of life through a very different lens.
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And I want to make a distinction clearly before we explore it.
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So concepts such as qi and yin, yang, liver energy and kidney essence, which we're going
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to talk about, belong to a traditional Chinese medicine and medical framework.
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They're not anatomical structures or measurable physiological mechanisms in the Western biomedical
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They're also just translation of two languages that are very different from one to the other.
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But traditional frameworks can still offer very useful ways of thinking about patterns,
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rhythms, depletion and adaptation.
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And it's very pragmatic too.
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Perimenopause is above all a period of transition.
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And traditional Chinese medicine has never viewed menopause simply as something going wrong.
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It sees it as a change, a change of season.
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There's an old Chinese philosophical idea that nature does not move in straight lines.
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Day becomes night, summer becomes autumn, activity becomes rest, expansion becomes contraction.
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And health comes partly from our ability to move with those transitions rather than demanding
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that the body remain permanently in summer.
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Now you might go, oh wow, this is autumn before winter, which is old age, that is so sad.
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Well, that's not quite how TCM views it.
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They see perimenopause as what they call a second spring.
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And I'm not saying that lightly.
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Spring is not necessarily calm.
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The weather changes quickly and temperatures rise and fall.
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Storms appear unexpectedly and everything is reorganizing beneath the surface.
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Perimenopause can feel much the same.
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Hormones fluctuate, cycles become less predictable, and the body can temporarily feel more sensitive
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But in Chinese medicine, this transition is not viewed simply as something being lost.
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It is also a redirection of energy.
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As the body gradually moves away from menstruation and reproduction, the resources once invested
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there can begin to turn inward.
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So perhaps perimenopause is not autumn after all.
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It's the unsettled weather of a second spring, a different season of growth, of strength,
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of wisdom, and of renewal.
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It's interesting because I've just worked on the podcast of Patricia.
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And people tell us they love podcasts with actual migrant heroes.
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And this is one of them.
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And Patricia explains that renewal beautifully as she looks forward to her new and regained
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life with much fewer migrants, regained independence, and self-confidence, and self-trust, and how
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she wonders how she's going to be when she turns 80.
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There's a beautiful illustration of this new spring.
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These are not just words.
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You'll hear it from her.
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The next decade can be gorgeous and a prolific one.
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And you will see she wants you to give hope, and I want that for you too.
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She's a great example to follow, a great leader in her own right.
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Now, in traditional Chinese medicine, the reproductive development and aging are closely
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associated with what is called the kidney system.
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And again, this does not mean your physical kidneys are failing.
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It refers to a broader traditional concept which is associated with development, with
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reproduction, resilience, and constitutional energy.
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And as women move toward menopause, traditional practitioners often describe a gradual decline
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in kidney yin, or kidney essence.
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And in simple language, you could think of yin as representing the body's cooling, nourishing,
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moistening, and grounding qualities.
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So what happens when that cooling and grounding capacity becomes relatively weaker?
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Traditional Chinese medicine would expect more signs of internal heat or internal instability.
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Hot flashes, night sweats, restlessness, poor sleep, dryness, a feeling of being tired but
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somehow unable to settle, and sometimes headache.
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From a Western perspective, we would describe vasomotor symptoms, neuroendocrine changes,
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and sleep disruption.
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Traditional Chinese medicine uses a different language.
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Less cooling, more apparent heat, different map, some overlapping territory.
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Now, why migraine may feel more explosive?
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So in traditional Chinese medicine, perinopause involves a second system, the liver system.
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It talks about liver yang rising and liver qi stagnation.
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And again, neither refers to liver disease.
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The traditional liver system is associated with keeping things moving smoothly, including
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qi, emotions, and the body's response to change.
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And so with prolonged stress, or poor sleep, emotional strain, hormonal fluctuations, or
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depletion, that movement may become less free.
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DCM describes this as liver qi stagnation, a kind of internal constraint, a kind of internal
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Instead of the energy circulating smoothly, it begins to feel held, compressed, or stuck.
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This can show up as neck and shoulder tension, irritability, a sense of pressure, sighing,
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digestive disruption, or headaches that build with stress.
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And when that constraint energy combines with deeper depletion, particularly declining yin,
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another pattern may appear, which is called the liver yang rising pattern.
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And the system has less anchoring and less capacity to regulate upward movement, so pressure
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and activity rise more easily toward the head.
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The traditional description can sound remarkably familiar, throbbing headache, pressure behind
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the eyes, dizziness, neck tension, irritability, sensitivity to stimulation, and the sensation
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of heat or pressure rising upward.
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I don't know if you relate to some of these symptoms, I hope you do.
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Now there's a Chinese image that captures this beautifully.
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When the root is weak, the branches shake.
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And so perimenopause can therefore be understood in TCM terms as involving both less smooth
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movement below, and more uncontrolled movement above.
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Liver qi may become more constrained, while depleted yin provides less anchoring for yang.
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Western medicine might describe hormonal instability and disrupted sleep, stress physiology, and
[20:39]
a lower migraine threshold.
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Traditional Chinese medicine uses a different language, but both are trying to describe
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a system that has become less stable, less adaptable, and more easily pushed into an
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Now there's something super interesting in Western science that is not linked to perimenopause
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on paper, that happens in parallel at the same time and mirrors what traditional medicine
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is saying beautifully.
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And the science does not prove the connection, but the parallel is almost impossible to ignore.
[21:06]
So from a Western physiological perspective, the liver organ undergoes measurable structural
[21:12]
and functional changes with aging.
[21:15]
A review published in the World Journal of Gastroenterology in 2015 reported that liver
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volume and hepatic blood flow gradually declined with age, with some estimates suggesting a
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reduction in liver volume of approximately 1% per year from around 40, eventually contributing
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to substantially lower liver volume in older adults.
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Interestingly, the age at which this decline becomes more apparent broadly coincides with
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the years in which many women enter perimenopause, and by age 80, so much later when we're well
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into menopause, this could amount to roughly a 30-35% reduction in liver volume compared
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And so current scientific evidence does not establish that perimenopause causes the reduction
[22:00]
For now, these should be understood as two biological processes that occur during an
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overlapping period of life, with their precise relationship still requiring further investigation.
[22:10]
So you see, when traditional Chinese medicine talks about liver G-stagnation, therefore
[22:14]
sometimes liver Yang rising, it's not just metaphorical, it's one of those beautiful
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spaces where we start to see overlap.
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And so here, traditional Chinese medicine is going to take the change holistically,
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and not say this is perimenopause and this is not, this is aging, and start to see the
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blend and how both need to be addressed to help support that beautiful second spring.
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And this is really important when it comes to migraine care.
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Now the lesson is not to fight harder.
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And this is where I think the Eastern perspective offers something particularly valuable.
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Western culture often responds to midlife symptoms by saying keep going and push through,
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sleep later, work harder, drink more coffee, do everything you were doing at 35 while your
[22:55]
physiology is reorganizing itself underneath you.
[22:59]
Traditional Chinese philosophy would probably question that approach.
[23:01]
Here is a saying attributed to classical Chinese thought, a tree that cannot bend eventually
[23:09]
Perimenopause may require more flexibility, your body may need greater consistency around
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sleep, more recovery after periods of intense activity, more regular nourishment, more respect
[23:19]
for heat, fatigue, and sensory overload, not because you are becoming weaker, but because
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your physiology is changing its operating conditions.
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And rhythm matters.
[23:30]
Traditional Chinese medicine places tremendous value on rhythm, eating regularly, sleeping
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at regular hours, matching activity with recovery, observing the seasons, noticing menstrual
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patterns, watching what happens before symptoms rather than only reacting after they appear.
[23:47]
And this overlaps surprisingly well with modern migraine management.
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Migraine brain often dislikes abrupt change, irregular sleep, sudden fasting, large changes
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in caffeine, dehydration, rapid changes in stress, and perhaps in hormonally sensitive
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people, rapid endocrine change.
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So whether we speak in the Western language of migraine thresholds and nervous system
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homeostasis, or the Eastern language of balance and harmonious flow, we arrive at a similar
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practical principle, reduce unnecessary volatility where you can.
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And this is something I personally relate to.
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I'm 43 now, and while my cycles are still quote-unquote normal, I can feel that my body
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My digestion is not quite as forgiving as it used to be, and I have become a bit more
[24:32]
mindful of when I eat and the rhythms I keep.
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Holidays are actually a good example.
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When the usual routines disappear and meals become lighter, heavier, or simply less predictable,
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I really feel disruption in my body.
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I enjoy the holidays, of course, but I also find myself generally looking forward to back-to-school
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time when life becomes more settled again, and I can return to a more natural flow, regularity
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And for me, that has been one of the clearest reminders that this stage of life is not necessarily
[25:00]
about something being wrong, but about realizing that my body may need a little more consistency
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and attention than it once did.
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It's subtle, but it's there.
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I can't ignore it, and I long for it.
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Now, what can you do today at home?
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So here's your exercise for today.
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Create what I call a migraine transition map.
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For the next few weeks, instead of tracking only whether you had a migraine, write down
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five things each day.
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Migraine symptoms, menstrual bleeding, sleep quality, hot flashes or night sweats, and
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You can also note unusual stress or medication use.
[25:34]
Do not obsess over perfection.
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The goal is simply to look for clusters.
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Maybe attacks repeatedly follow two poor nights of sleep.
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Maybe they appear around bleeding.
[25:44]
Maybe hot flash nights and migraine days travel together.
[25:47]
This information can turn my migraine or completely random into more insights that you can make
[25:53]
And while your hormones may not be controllable from day to day, give your nervous system
[25:58]
as much predictability as you reasonably can.
[26:01]
Eat regularly, stay hydrated, protect your sleep schedule, avoid dramatic swings in caffeine,
[26:07]
and build short periods of recovery into your day.
[26:10]
If your migraine pattern has changed significantly, attacks have become much more frequent and
[26:15]
you're considering hormonal treatment, bring that diary to a clinician who understands
[26:19]
migraine and menopause.
[26:22]
And of course, you can do all of that in the Migraine Heroes app.
[26:26]
That's all for today.
[26:27]
I hope this episode added another piece to your migraine puzzle.
[26:31]
If you'd like to apply what we've discussed to your own life, you can find us by searching
[26:36]
Migraine Heroes in the App Store or Google Play.
[26:40]
Look for the green icon with the love heart in the brain.
[26:43]
Migraine is complex, but it's not random.
[26:46]
And every step forward brings us closer to lasting relief.
[26:50]
Your body has a story to tell.
[26:51]
Let's keep listening.
[26:52]
I will be back with you soon.