Insight: How Omega-3s Soothe the Migraine Brain

Not all fats are created equal—and some can be powerful allies for your migraine-prone brain.

In this episode of Migraine Heroes Podcast, we dive deep into the world of Omega-3 fatty acids and their remarkable ability to soothe inflammation, stabilize blood vessels, and support your brain’s natural resilience against migraine attacks. Hosted by Diane Ducarme, who bridges neuroscience and Traditional Chinese Medicine, this conversation reveals how the right kind of fat can become medicine.

You’ll discover:

🟡 Exactly how Omega-3s affect inflammation, vascular health, and migraine physiology

🟡 The risks and cautions around Omega-3s—when balance with Omega-6 matters most

🟡 Practical guidelines for how to consume Omega-3s safely—and who benefits most from increasing them, increasing them

We’ll explore how modern diets often tilt toward inflammation, how this imbalance alters the vascular tone of migraine sufferers, and how returning to nature’s fats—found in wild fish, flax, and even chia—can help restore internal calm.

This isn’t just nutrition—it’s neurobiology in action. When your brain is inflamed, every trigger feels louder. When it’s nourished with Omega-3s, it learns to whisper again.

References:

• Dietary Omega-3 & Migraine Reduction: A 2021 randomized trial in BMJ by Ramsden et al. showed that shifting diet to increase n-3 (EPA/DHA) and/or reduce n-6 fatty acids lowered headache frequency and severity in migraine sufferers. Read the full trial here.
• Molecular Mechanisms of Omega-3 in Migraine: A 2017 review in PMC by Soveyd et al. detailed how omega-3 fatty acids modulate neuroinflammation, oxidative stress, and nociception—pathways shared with depression. Learn more here.
• Effect of Omega-3 on Sleep Quality – Journal of Clinical Biochemistry & Nutrition, 2024: A 2024 meta-analysis by Shimizu et al. found that omega-3 long-chain polyunsaturated fatty acids significantly improved sleep efficiency and subjective sleep quality—mechanisms that could influence migraine and depression via better restorative rest. Read the full review here.

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Disclaimer: This podcast is for informational purposes only and does not substitute for providing medical advice. Always consult your healthcare professional before making any health-related decisions.

For women, men, and children who suffer from migraine disease, Migraine Heroes is your go-to resource for understanding, managing, and overcoming migraine attacks.

We cover all types of migraines and related headaches, including primary and secondary migraines, chronic migraines, and cluster migraines. We dive deep into the complexities of migraine with aura and migraine without aura, as well as rarer forms like hemiplegic migraine, retinal migraine, and acephalgic migraine (silent migraine). Our discussions also extend to cervicogenic headaches, ice pick headaches, and pressure headaches, which often mimic migraine or contribute to overall migraine burden.